These Are the Most Expensive Hotels Rooms in Las Vegas

5. Palms Casino Resort

The founder George Maloof outdid himself with this one. The Palms is a beautiful, newly reopened hotel with modern amenities, high-end dining options, ample rooms, and an opulent ambiance. The Empathy suite is the most expensive hotel room in the city at $100,000 a night. Also, the booking arrangement stipulates a minimum of two nights to secure this suite. It occupies 9000 square feet, and guests staying here enjoy perks like a private pool, a dedicated massage room, casino credit, a large bar, a water tank with sharks, and more.